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1. Pneumotox is a repository built from over 35,000 published bibliographic references (mainly indexed in PubMed) individually reviewed and rearranged by causative drugs (n>1,500) including chemicals and substances of abuse, be they administered buccally, parenterally, topically or via inhalation (e.g. e-cigarettes, vaping, inhalants, gases), and by patterns of respiratory involvement (n>650).

2. In any patient, particularly when severe respiratory failure, ARDS or acute asthma is present, survey of exposure to drugs, substances, and/or chemicals must be done carefully with patient, family, health professionals, and/or pharmacy.

3. If a drug reaction is listed in Pneumotox, this does not equate diagnosis in the patient.

4. You may access Pneumotox by drug names (International Nonproprietary Names or INN, alphabetical) or patterns grouped by families.

5. Please rate the likelihood for drug causality in every case, using the ‘Diagnosing DIRD’ prompt/button and the Naranjo scale to decide whether to withdraw or prudently continue the drug.

6. Pneumotox is an aid to the investigation and diagnosis of respiratory and cardiac diseases/reactions suspected of being drug-induced/iatrogenic.

7. Conversely, lack of description in the literature or in Pneumotox does not rule out the diagnosis.

8. Where in doubt, consider double-checking PubMed, your affiliated Safety for Medicines Department/Agency and the Pharmacovigilance Department of drug companies.

9. Pneumotox is designed to provide information and bibliography more quickly and extensively than a manual search on conventional databases may do.

10. Please examine what INN are exactly contained in any suspected proprietary drug, including excipients.

11. Early sampling of body fluids for drug and metabolites is indicated when appropriate shortly upon admission, particularly in the severely ill.