Dialysis of Drugs Guide for Pc

1. The website provides specific information about factors that influence drug dialyzability and special considerations, such as CRRT, plasmapheresis and drugs of abuse.

2. The website also includes a table presenting sieving coefficient data from in vitro and in vivo evaluations, which can be used to predict dosing requirements in CRRT, and a table regarding removal of drugs of abuse.

3. For many drugs, including newly-approved medications, investigational agents and medications available in other countries, there have been no dialysis pharmacokinetic studies.

4. The guidelines contained in this application are designed to provide extensive, easy-to-read information regarding the dialyzability of drugs.

5. Variations in the duration of dialysis, blood and dialysate flow rates, dialysis membranes, and whether peritoneal dialysis is continuous or intermittent, will all affect drug removal.

6. No information is provided on drug dialyzability with continuous renal replacement therapy (CRRT) or with plasmapheresis.

7. For additional information on specific drugs, the reader should consult the primary literature.

8. Users of this application are referred to for background and explanatory material to assist in the interpretation of the tabular data.

9. These guidelines distinguish between conventional hemodialysis and high permeability (high-flux) hemodialysis where such data are available.

10. Users must be familiar with this information prior to using the content of this application.

11. The app requires a one year non-renewing subscription to access application data.

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