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1. All data and definitions are based on the Updated Breast Chapter - AJCC Cancer Staging Manual 8th Edition, released on November 10th, 2017 that included the classic Anatomic Stage Group and the new and revolutionary Prognostic Stage Group (divided in Clinical Prognostic Stage and Pathological Prognostic Stage) with the incorporation of biomarker factors that predict more accurately cancer outcome for a more personalized and precise approach.

2. Licensed by AJCC, TNM8 Breast Cancer Calculator is an updated, complete, intuitive, and user-friendly tool for Breast Cancer Staging based on the TNM 8th Edition - AJCC Cancer Staging Manual - Updated Breast Chapter with: Anatomic Stage, Clinical Prognostic Stage, and Pathological Prognostic Stage.

3. This App provides the quantification of the category change of the Clinical Prognosis Stage (cPS) and also the Pathological Prognostic Stage (pPS) in relation to the Anatomic Stage (AS) expressed in the Staging Line with the symbol +1, +2, +3 in case of worsening in the Prognostic Staging or -1, -2, -3 in case of improvement in the Prognostic Staging.

4. The Pathological Prognostic Stage will be used to assign stage for patients who have the surgical resection as the initial treatment of their cancer before any systemic or radiation therapy.

5. The Anatomic Stage is based solely on the anatomic extent of cancer as defined by the T, N, and M categories and should be used for all patients even if prognostic staging is possible.

6. Pathological Prognostic Stage does not apply to patients treated with chemotherapy, hormone therapy or radiation prior to surgical resection (neoadjuvant therapy).

7. Genomic profile information can be used for the Pathological Prognostic Stage (pT1-T2 N0, HER2- and ER+).

8. Genomic Profiles were also incorporated as a prognostic factor for eligible cases (pT1-T2 N0 M0 HER2- and ER+) in the Pathological Prognostic Stage.

9. The Clinical Prognostic Stage will be used to assign stage for all patients based on history, physical examination, imaging studies, and relevant biopsies.

10. Genomic profile information is not included in Clinical Prognostic Stage.

11. Pathological Prognostic Stage is determined by pT, pN, c/pM, G, HER2, ER, and PR.